LONG-TERM EFFECT OF BIFIDOBACTERIA AND NEOSUGAR ON PRECURSOR LESIONS OF COLONIC-CANCER IN CF1 MICE

被引:60
作者
KOO, M
RAO, AV
机构
[1] Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1991年 / 16卷 / 3-4期
关键词
D O I
10.1080/01635589109514163
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This investigation was undertaken to study the role of Bifidobacteria and bifidogenic factor Neosugar in the process of 1,2-dimethylhydrazine-induced colonic carcinogenesis in CF1 mice. Intestinal colonization and selective proliferation of Bifidobacteria were achieved by oral administration of indigenous Bifidobacteria and the incorporation of 5% Neosugar in the diet of animals. The Bifidobacteria were isolated from the feces of CF1 mice and were identified to be Bifidobacterium pseudolongum biovar b. This incidence of aberrant crypts and foci were significantly lower 38 weeks after the last injection of the carcinogen in animals fed Bifidobacteria than in animals treated with the carcinogen alone. The aberrance also appeared to be confined to the more distal end of the colon in animals fed bifidogenic diet. Such changes in the precursor lesions of colonic carcinogenesis are presumably due to the increase in the number of Bifidobacteria and their acidifying action in the lower intestinal tract of the animals.
引用
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页码:249 / 257
页数:9
相关论文
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