THE IGG SUBCLASS ANTIBODY-RESPONSE TO AN INHALANT ANTIGEN (DERMATOPHAGOIDES-PTERONYSSINUS) DURING THE 1ST YEAR OF LIFE - EVIDENCE FOR EARLY STIMULATION OF THE IMMUNE-SYSTEM FOLLOWING NATURAL EXPOSURE

被引:47
作者
MARIANI, F
PRICE, JF
KEMENY, DM
机构
[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,GUYS CAMPUS,LONDON SE1 9RT,ENGLAND
[2] UNIV BARI POLICLIN,CATTEDRA ALLERGOL & IMMUNOL CLIN,BARI,ITALY
[3] UNIV LONDON KINGS COLL,SCH MED,DEPT CHILD HLTH,LONDON WC2R 2LS,ENGLAND
关键词
D O I
10.1111/j.1365-2222.1992.tb00111.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
This study investigates the early humoral immune response following natural exposure to an inhalant antigen (Dermatophagoides pteronyssinus) in 36 babies, from birth until 1 year of age. The total IgG and subclass 1 and 4 D. pteronyssinus-specific antibody levels were assayed in sera collected at 7 days, 3 and 12 months by ELISA. After an initial fall, due to the progressive loss of maternal antibodies, an IgG specific response to D. pteronyssinus was seen between 3 and 12 months. This was restricted to the IgG1 subclass when the values at 12 months were significantly higher than those detected at the third month (P < 0.001, paired t test). No D. pteronyssinus-specific IgG4 antibody was detected in any subject at any of the time points tested. The present study demonstrates that inhalant as well as food antigens are able to stimulate the immune system during the first year of life and that the antibodies produced are of the IgG1 subclass.
引用
收藏
页码:29 / 33
页数:5
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