DIFFERENTIAL EXPRESSION OF VIMENTIN IN RAT PROSTATIC TUMORS

被引：23

作者：

BUSSEMAKERS, MJG ^{[1
]}

VERHAEGH, GWCT ^{[1
]}

VANBOKHOVEN, A ^{[1
]}

DEBRUYNE, FMJ ^{[1
]}

SCHALKEN, JA ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,6500 HB NIJMEGEN,NETHERLANDS

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91866-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Differential hybridization analysis was used to identify molecular differences between a relative benign and a highly aggressive rat prostatic tumor derived from the Dunning R-3327-H adenocarcinoma. From the several differentially expressed mRNAs identified, we here report the characterization of pBUS51 which encodes a transcript highly expressed in all anaplastic Dunning tumors. Only a very low expression was detectable in normal rat prostate or in the differentiated tumors of the Dunning system. Nucleotide sequence analysis and computer-assisted database comparison revealed that pBUS51 was highly homologous to vimentin and therefore likely the rat homolog of this protein. © 1992.

引用

页码：1254 / 1259

页数：6

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