THE SYNTHESIS OF NOVEL PROSTAGLANDIN ANALOGS VIA CYCLOADDITION REACTIONS

被引：10

作者：

COLLINGTON, EW

FINCH, H

MONTANA, JG

TAYLOR, RJK

机构：

[1] UNIV E ANGLIA, SCH CHEM SCI, NORWICH NR4 7TJ, NORFOLK, ENGLAND

[2] GLAXO GRP RES LTD, WARE SG12 0DJ, HERTS, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 07期

关键词：

D O I：

10.1039/p19900001839

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the cyclobutane prostaglandin analogues (4) and (5), and their subsequent conversion to the γ-lactones (6) and (7), γ-lactam (8) and cyclopentanone (9) is described. The cornerstone of the synthetic strategy is the intermolecular [2 + 2] cycloaddition of dichloroketene to a suitably functionalised enol ether.

引用

页码：1839 / 1846

页数：8

共 33 条

[1]

[Anonymous], 1986, AM J GASTROENTEROL, V81, P1021

[2] ISOMERIZATION OF ALLYL ETHERS CATALYZED BY CATIONIC IRIDIUM COMPLEX [IR(CYCLO-OCTA-1,5-DIENE)(PMEPH2)2]PF6 - HIGHLY STEREOSELECTIVE ROUTE TO TRANS-PROPENYL ETHERS [J].