RENAL PATHOLOGY IN OWL MONKEYS IN PLASMODIUM-FALCIPARUM VACCINE TRIALS

被引：8

作者：

ISEKI, M

BRODERSON, JR

PIRL, KG

IGARASHI, I

COLLINS, WE

AIKAWA, M

机构：

[1] CTR DIS CONTROL,OFF SCI SERV,ATLANTA,GA 30333

[2] CTR DIS CONTROL,MALARIA BRANCH,ATLANTA,GA 30333

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 43卷 / 02期

关键词：

D O I：

10.4269/ajtmh.1990.43.130

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Renal specimens of 16 owl monkeys (Aotus vociferans) were studied by light microscopy and immunohistochemistry during a vaccine trial with recombinant proteins of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. Deposition of IgG, C3, and P. falciparum antigens in the mesangium was demonstrated by the peroxidase anti-peroxidase (PAP) method. A relationship between the severity of parasitemia at the time of death and the presence of nephropathy was not apparent.

引用

页码：130 / 138

页数：9

共 38 条

[1] GLOMERULOPATHY IN SQUIRREL-MONKEYS WITH ACUTE PLASMODIUM-FALCIPARUM INFECTION [J].