5-(AMINOMETHYL)-3-ARYLDIHYDROFURAN-2(3H)-ONES, A NEW CLASS OF MONOAMINE OXIDASE-B INACTIVATORS

被引：22

作者：

DING, ZZ

SILVERMAN, RB

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208

[2] NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60208

[3] NORTHWESTERN UNIV,INST NEUROSCI,EVANSTON,IL 60208

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 05期

关键词：

D O I：

10.1021/jm00083a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.

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页码：885 / 889

页数：5

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