THE RELATIONSHIP BETWEEN C-ERBB-2 EXPRESSION, S-PHASE FRACTION AND PROGNOSIS IN BREAST-CANCER

被引：142

作者：

OREILLY, SM

BARNES, DM

CAMPLEJOHN, RS

BARTKOVA, J

GREGORY, WM

RICHARDS, MA

机构：

[1] GUYS & ST THOMAS HOSP, IMPERIAL CANC RES FUND, CLIN ONCOL UNIT, LONDON SE1 9RT, ENGLAND

[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, ST THOMAS HOSP, RICHARD DIMBLEBY DEPT CANC RES, LONDON SE1 7EH, ENGLAND

[3] RES INST CLIN & EXPTL PATHOL, BRNO, CZECHOSLOVAKIA

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 03期

关键词：

D O I：

10.1038/bjc.1991.102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer, c-erbB-2 staining was independent of age, tumour size, number of nodes involved, tumour grade and DNA ploidy, but was more common in oestrogen receptor (ER) negative tumours (P = 0.02) and progesterone receptor (PgR) negative tumours (P = 0.03). A weak correlation between c-erbB-2 staining and SPF was observed (r = 0.18). Amongst women with node negative disease, SPF was significantly related to relapse free survival (RFS, P = 0.04) while c-erbB-2 staining was not (P = 0.2). In contrast, both SPF (P = 0.002) and c-erbB-2 staining (P = 0.016) provided significant prognostic information on RFS for women with node positive disease. Multivariate analysis showed that c-erbB-2 staining and SPF gave independent information on RFS for women with node positive disease.

引用

页码：444 / 446

页数：3

共 25 条

[21] OVEREXPRESSION OF THE C-ERBB-2 ONCOPROTEIN IN HUMAN-BREAST CARCINOMAS - IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION [J].