THE EFFECT OF A NEW VITAMIN-D ANALOG, 22-OXA-1-ALPHA,25(OH)2D3, ON BONE-MINERAL METABOLISM IN NORMAL-MALE RATS

被引：10

作者：

TAKIZAWA, M

FALLON, M

STEIN, B

EPSTEIN, S

机构：

[1] ALBERT EINSTEIN MED CTR,NO DIV,DIV ENDOCRINOL & METAB,YORK & TABOR RD,PHILADELPHIA,PA 19141

[2] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,PHILADELPHIA,PA 19107

来源：

CALCIFIED TISSUE INTERNATIONAL | 1992年 / 50卷 / 06期

关键词：

22-OXA-1-ALPHA; 25; DIHYDROXYVITAMIN-D3; 1,25(OH)2D3; BONE HISTOMORPHOMETRY; BONE GLA PROTEIN;

D O I：

10.1007/BF00582166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The in vivo effects of 22-oxa-1-alpha,25 dihydroxyvitamin D3 (OCT), on bone mineral metabolism were investigated in normal male Sprague-Dawley rats. The rats were administered either vehicle (control), low-dose OCT (25 ng/100 g body weight), or high-dose OCT (250 ng/100 g body wt). High-dose OCT increased serum ionized calcium (P < 0.05) and decreased serum parathyroid hormone (PTH) (P < 0.05) at all time points and increased serum bone Gla protein on days 7 and 28 (P < 0.05) compared with controls. Low-dose OCT decreased serum PTH at all the time points (P < 0.05) compared with controls. Tibial bone histomorphometry showed no significant differences between the two doses of OCT and controls. We found that OCT has minimal direct effects on bone metabolism in normal male rats in contrast to 1,25 dihydroxyvitamin D3. This property may be advantageous in the treatment with OCT of cell-proliferative diseases.

引用

收藏

页码：521 / 523

页数：3

相关论文

共 17 条

[1] DIFFERENTIATION OF MOUSE MYELOID-LEUKEMIA CELLS INDUCED BY 1-ALPHA,25-DIHYDROXYVITAMIN-D3 [J].

ABE, E ;

MIYAURA, C ;

SAKAGAMI, H ;

TAKEDA, M ;

KONNO, K ;

YAMAZAKI, T ;

YOSHIKI, S ;

SUDA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (08) :4990-4994

[2] SYNTHETIC ANALOGS OF VITAMIN-D3 WITH AN OXYGEN ATOM IN THE SIDE-CHAIN SKELETON - A TRAIL OF THE DEVELOPMENT OF VITAMIN-D COMPOUNDS WHICH EXHIBIT POTENT DIFFERENTIATION-INDUCING ACTIVITY WITHOUT INDUCING HYPERCALCEMIA [J].

ABE, J ;

MORIKAWA, M ;

MIYAMOTO, K ;

KAIHO, SI ;

FUKUSHIMA, M ;

MIYAURA, C ;

ABE, E ;

SUDA, T ;

NISHII, Y .

FEBS LETTERS, 1987, 226 (01) :58-62

[3] A SYNTHETIC ANALOG OF VITAMIN-D3, 22-OXA-1-ALPHA,25-DIHYDROXYVITAMIN-D3, IS A POTENT MODULATOR OF INVIVO IMMUNOREGULATING ACTIVITY WITHOUT INDUCING HYPERCALCEMIA IN MICE [J].

ABE, J ;

TAKITA, Y ;

NAKANO, T ;

MIYAURA, C ;

SUDA, T ;

NISHII, Y .

ENDOCRINOLOGY, 1989, 124 (05) :2645-2647

[4] THE NONCALCEMIC ANALOG OF VITAMIN-D, 22-OXACALCITRIOL, SUPPRESSES PARATHYROID-HORMONE SYNTHESIS AND SECRETION [J].

BROWN, AJ ;

RITTER, CR ;

FINCH, JL ;

MORRISSEY, J ;

MARTIN, KJ ;

MURAYAMA, E ;

NISHII, Y ;

SLATOPOLSKY, E .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (03) :728-732

[5]

DUSSO AS, 1990, J BONE MINER RES S, V5, pS202

[6] 1,25 DIHYDROXYVITAMIN-D3 MODIFIES CYCLOSPORINE-INDUCED BONE LOSS [J].

EPSTEIN, S ;

SCHLOSBERG, M ;

FALLON, M ;

THOMAS, S ;

MOVSOWITZ, C ;

ISMAIL, F .

CALCIFIED TISSUE INTERNATIONAL, 1990, 47 (03) :152-157

[7]

FINCH J, 1990, J BONE MINER RES S, V5, pS202

[8] 1-ALPHA,25-DIHYDROXYVITAMIN-D3 AND 1-ALPHA-HYDROXYVITAMIN-D3 PROLONG SURVIVAL-TIME OF MICE INOCULATED WITH MYELOID-LEUKEMIA CELLS [J].

HONMA, Y ;

HOZUMI, M ;

ABE, E ;

KONNO, K ;

FUKUSHIMA, M ;

HATA, S ;

NISHII, Y ;

DELUCA, HF ;

SUDA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (01) :201-204

[9] REGULATION OF TERMINAL DIFFERENTIATION OF CULTURED MOUSE EPIDERMAL-CELLS BY 1-ALPHA,25-DIHYDROXYVITAMIN-D3 [J].

HOSOMI, J ;

HOSOI, J ;

ABE, E ;

SUDA, T ;

KUROKI, T .

ENDOCRINOLOGY, 1983, 113 (06) :1950-1957

[10] 1,25-DIHYDROXYVITAMIN-D3 MODULATES GLUCOCORTICOID-INDUCED ALTERATION IN SERUM BONE GLA PROTEIN AND BONE HISTOMORPHOMETRY [J].

JOWELL, PS ;

EPSTEIN, S ;

FALLON, MD ;

REINHARDT, TA ;

ISMAIL, F .

ENDOCRINOLOGY, 1987, 120 (02) :531-536