ASTROCYTE ENDOTHELIAL INTERACTION - PHYSIOLOGY AND PATHOLOGY

被引:121
作者
ABBOTT, NJ
REVEST, PA
ROMERO, IA
机构
基金
英国惠康基金;
关键词
ASTROCYTE; BLOOD BRAIN BARRIER; INDUCTION; PATHOLOGY; TOXICOLOGY;
D O I
10.1111/j.1365-2990.1992.tb00808.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The blood-brain barrier of higher vertebrates is formed by the layer of endothelial cells lining the brain microvessels. The close anatomical association between endothelial cells and perivascular astrocytic end feet suggests cooperation between these cell types in forming and maintaining the blood-brain barrier. This review considers evidence from grafting experiments, developmental studies and culture models of the brain endothelium, concerning the inductive influences acting on the endothelium, and from endothelial cells acting on perivascular astrocytes. Examples from pathology and neurotoxicology which may involve breakdown of induction are also considered.
引用
收藏
页码:424 / 433
页数:10
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