APOLIPOPROTEIN-E AND THE APOLIPOPROTEIN E-DEFICIENT MOUSE

被引：127

作者：

PLUMP, AS

BRESLOW, JL

机构：

[1] Rockefeller University, New York, NY 10021

来源：

ANNUAL REVIEW OF NUTRITION | 1995年 / 15卷

关键词：

LIPOPROTEIN METABOLISM; ATHEROSCLEROSIS; GENE KNOCKOUT; MOUSE GENETICS;

D O I：

10.1146/annurev.nu.15.070195.002431

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate this same genetic variation in determining susceptibility to Alzheimer's disease. An apoE-deficient mouse has been created to further understand the role of apoE in these areas. This review briefly discusses the biological and clinical importance of this protein and describes the early experiments performed in the apoE-deficient mouse.

引用

页码：495 / 518

页数：24

共 108 条

[1] MECHANISM OF HYPERTRIGLYCERIDEMIA IN HUMAN APOLIPOPROTEIN-(APO)-CIII TRANSGENIC MICE - DIMINISHED VERY LOW-DENSITY-LIPOPROTEIN FRACTIONAL CATABOLIC RATE ASSOCIATED WITH INCREASED APO-CIII AND REDUCED APO-E ON THE PARTICLES [J].