NEUROPEPTIDE-Y INCREASES THE CORTICOTROPIN-RELEASING FACTOR MESSENGER-RIBONUCLEIC-ACID LEVEL IN THE RAT HYPOTHALAMUS

被引：113

作者：

SUDA, T ^{[1
]}

TOZAWA, F ^{[1
]}

IWAI, I ^{[1
]}

SATO, Y ^{[1
]}

SUMITOMO, T ^{[1
]}

NAKANO, Y ^{[1
]}

YAMADA, M ^{[1
]}

DEMURA, H ^{[1
]}

机构：

[1] NATL CHILDRENS MED RES CTR,GENET LAB,TOKYO,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 18卷 / 04期

关键词：

NEUROPEPTIDE-Y; CORTICOTROPIN-RELEASING FACTOR; ADRENOCORTICOTROPIN; PROOPIOMELANOCORTIN; PITUITARY; HYPOTHALAMUS;

D O I：

10.1016/0169-328X(93)90094-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropeptide Y (NPY) has a stimulatory effect on adrenocorticotropin (ACTH) and corticotropin-releasing factor (CRF) release. In the present study, to investigate the effect of NPY on CRF synthesis, the effect of centrally administered NPY on CRF messenger RNA (mRNA) levels in rat hypothalamus was examined under pentobarbital anesthesia. The administration of 0.01, 0.1 and 1 nmol of NPY into the lateral ventricle dose-dependently Increased the plasma ACTH levels, as well as the levels of proopiomelanocortin mRNA in the anterior pituitary. The CRF mRNA level in the hypothalamus also increased after administration of 0.1 and 1 nmol of NPY in a dose-dependent manner. The administration of 3 nmol of phentolamine or propranolol failed to block 0.1 nmol NPY-induced ACTH release or 1 nmol NPY-stimulated CRF mRNA levels in the hypothalamus. These results Indicate that the central administration of NPY increases the CRF mRNA levels in the hypothalamus and the probable CRF release, which increases the proopiomelanocortin mRNA levels and ACTH secretion in the anterior pituitary. Therefore, NPY seems to play a physiological role in the regulation of the release and synthesis of CRF in the hypothalamus.

引用

页码：311 / 315

页数：5

共 31 条

[1] NEUROPEPTIDE-Y DISTRIBUTION IN HUMAN-BRAIN [J].