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IMMUNOHISTOCHEMICAL STUDY OF ALPHA-2 MACROGLOBULIN RECEPTOR IN ALZHEIMER AND CONTROL POSTMORTEM HUMAN BRAIN

被引：69
作者：
TOOYAMA, I
KAWAMATA, T
AKIYAMA, H
MOESTRUP, SK
GLIEMANN, J
MCGEER, PL
机构：
[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,DEPT PSYCHIAT,VANCOUVER V6T 1Z3,BC,CANADA
[2] AARHUS UNIV,INST MED BIOCHEM,DK-8000 AARHUS,DENMARK
来源：
MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1993年 / 18卷 / 1-2期
关键词：
ALPHA-2 MACROGLOBULIN RECEPTOR; IMMUNOHISTOCHEMISTRY; SENILE PLAQUE; NEUROFIBRILLARY TANGLE; ALZHEIMER DISEASE; HIPPOCAMPUS; GLIA;
D O I：
10.1007/BF03160029
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Localization of the alpha2, macroglobulin receptor (alpha2MR) was studied in postmortem human brain tissue of Alzheimer disease (AD) and age-matched control cases with a monoclonal antibody (A2MRalpha2) to the receptor. In control cases alpha2MR was detected in neurons, glia, and some capillaries. Neuronal staining was most conspicuous in the hippocampus and entorhinal cortex. In AD, alpha2MR immunoreactivity was enhanced. The staining intensity of some neurons was increased, as was the number of positive glial cells. In addition, senile plaques, tangles, and dystrophic neurites were strongly stained. These results suggest that alpha2MR is involved in AD pathology.
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页码：153 / 160
页数：8
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