TARGETED DISRUPTION OF THE GATA3 GENE CAUSES SEVERE ABNORMALITIES IN THE NERVOUS-SYSTEM AND IN FETAL LIVER HEMATOPOIESIS

被引：489

作者：

PANDOLFI, PP

ROTH, ME

KARIS, A

LEONARD, MW

DZIERZAK, E

GROSVELD, FG

ENGEL, JD

LINDENBAUM, MH

机构：

[1] NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60208

[2] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HAEMATOL,LONDON W12 0HS,ENGLAND

[3] NATL INST MED RES,GENE STRUCT & EXPRESS LAB,LONDON NW7 1AA,ENGLAND

[4] ERASMUS UNIV ROTTERDAM,MGC DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS

来源：

NATURE GENETICS | 1995年 / 11卷 / 01期

关键词：

D O I：

10.1038/ng0995-40

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

GATA-3 is one member of a growing family of related transcription factors which share a strongly conserved expression pattern in all vertebrate organisms. In order to elucidate GATA-3 function using a direct genetic approach, we have disrupted the murine gene by homologous recombination in embryonic stem cells. Mice heterozygous for the GATA3 mutation are fertile and appear in all respects to be normal, whereas homozygous mutant embryos die between days 11 and 12 postcoitum (p.c.) and display massive internal bleeding, marked growth retardation, severe deformities of the brain and spinal cord, and gross aberrations in fetal liver haematopoiesis.

引用

页码：40 / 44

页数：5

共 33 条

[1] MOUSE GATA-4 - A RETINOIC ACID-INDUCIBLE GATA-BINDING TRANSCRIPTION FACTOR EXPRESSED IN ENDODERMALLY DERIVED TISSUES AND HEART [J].