POLYOMAVIRUS PERSISTS IN CD4/8 DOUBLE-KNOCKOUT, BUT NOT IN CD4 OR CD8 SINGLE-KNOCKOUT MICE

被引:12
作者
BERKE, Z
WEN, T
JIN, S
KLEIN, G
DALIANIS, T
机构
[1] HUDDINGE UNIV HOSP, KAROLINSKA INST, DEPT CLIN VIROL, S-14186 HUDDINGE, SWEDEN
[2] KAROLINSKA INST, CTR MICROBIOL & TUMOR BIOL, S-17177 STOCKHOLM, SWEDEN
关键词
D O I
10.1006/viro.1995.1482
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The effects of incomplete immunocompetence on possible persistence and reactivation of polyomavirus in adult mice were investigated by a polyomavirus-specific polymerase chain reaction (PCR). The presence of virus DNA was followed between 4 days and 2 months postinfection (p.i.) in polyomavirus-infected normal adult A/Sn mice and CD4(-/-) and CD8(-/-) single-knockout, as well as CD4(-/-)8(-/-) double-knockout BALB/c or C57BL/6 mice. The same study was performed in A/Sn mice immunosuppressed by thymectomy (THX), cytosine-beta-D-arabinofuranoside (Ara-C) treatment, and total body irradiation (TBI). Primary polyomavirus infection of CD4(-/-) or CD8(-/-) single-knockout mice was similar to that obtained in normal adult mice when followed by PCR. Viral DNA was detected in a limited number of organs during 4 weeks p.i., but was no longer observed after 1-2 months. In contrast, the virus could be detected in most organs of CD4(-/-)8(-/-) double-negative mice and in THX-, Ara-C-, and TBI-treated adult mice and was still present 1-2 months p.i. In polyomavirus-infected normal adult mice a later immunosuppression did not lead to reactivation of the virus. Furthermore, if a second challenge of polyomavirus was administered 4 weeks after primary infection in both normal or recently immunosuppressed mice no viral DNA could be detected by PCR. (C) 1995 Academic Press, Inc.
引用
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页码:268 / 271
页数:4
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