PREPARATION AND EVALUATION OF BIODEGRADABLE POLYMERIC SYSTEMS FOR THE INTRA-ARTICULAR DELIVERY OF DRUGS

被引：106

作者：

RATCLIFFE, JH

HUNNEYBALL, IM

SMITH, A

WILSON, CG

DAVIS, SS

机构：

[1] BOOTS CO PLC, RES DEPT, NOTTINGHAM NG2 3AA, ENGLAND

[2] UNIV NOTTINGHAM, DEPT PHARM, NOTTINGHAM NG7 2UH, ENGLAND

[3] UNIV NOTTINGHAM, DEPT PHARMACOL, NOTTINGHAM NG7 2UH, ENGLAND

[4] UNIV NOTTINGHAM, DEPT PHYSIOL, NOTTINGHAM NG7 2UH, ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1984年 / 36卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1984.tb04419.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Colloidal suspensions of 4 biodegradable polymers, polylactic acid (PLA), polybutylcyanoacrylate (PBCA), gelatin (PG) and albumin (PA), were prepared within the size range 1-10 .mu.m. In-vivo biocompatibility tests with synovial tissues were carried out to assess the irritancy of the polymers following intraarticular injection into rabbit knee joints. PLA, PBCA and PG caused joint inflammation whereas PA was well tolerated by the tissues. PA microspheres may provide a means of sustaining the release and reducing the rate of clearance of drugs from the knee joint.

引用

页码：431 / 436

页数：6

共 33 条

[1]

BECK LR, 1979, FERTIL STERIL, V31, P545

[2]

BENACEREFF B, 1975, PHYSIOPATHOLOGY RETI

[3] THERMOGRAPHIC AND CLINICAL COMPARISON OF 3 INTRA-ARTICULAR STEROID PREPARATIONS IN RHEUMATOID-ARTHRITIS [J].