P2 SPECIFIC LYMPHOCYTE-TRANSFORMATION IN GUILLAIN-BARRE-SYNDROME AND CHRONIC IDIOPATHIC DEMYELINATING POLYRADICULONEUROPATHY

被引：18

作者：

TAYLOR, WA

BROSTOFF, SW

HUGHES, RAC

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMASS HOSP,GUYS HOSP,DEPT NEUROL,LONDON SE1 9RT,ENGLAND

[2] MED UNIV S CAROLINA,DEPT NEUROL,CHARLESTON,SC 29425

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 104卷 / 01期

关键词：

GUILLAIN-BARRE SYNDROME; LYMPHOCYTE TRANSFORMATION; P2-PROTEIN; PEPTIDE;

D O I：

10.1016/0022-510X(91)90215-S

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Thymidine incorporation proliferation assays to whole bovine P2 protein and its 58-81 and 14-25 synthetic peptides were performed on blood mononuclear cells from ten patients with Guillain-Barre syndrome (GBS), six patients with chronic idiopathic demyelinating polyradiculoneuropathy (CIDP), and age and sex matched normal subjects. The only patients whose cells showed any response were two out of four with very early GBS. One responded to P2 and both synthetic peptides. One responded to P2 but to neither peptide. The results support a role for cell mediated immunity to P2 protein in some patients with Guillain-Barre syndrome.

引用

页码：52 / 55

页数：4

共 33 条

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