PSYCHOTIC ILLNESS IN MULTIPLE-SCLEROSIS - A CLINICAL AND MAGNETIC-RESONANCE-IMAGING STUDY

被引:93
作者
FEINSTEIN, A
DUBOULAY, G
RON, MA
机构
[1] Institute of Neurology, London WC1N 3BG, Queen Square
基金
英国惠康基金;
关键词
D O I
10.1192/bjp.161.5.680
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Ten patients with multiple sclerosis (MS) and psychosis were assessed using the Present State Examination, and matched retrospectively with respect to age, disability, duration of symptoms, and disease type with 10 MS patients without psychosis. Both groups underwent MRI of the brain. There was a trend for the psychotic group to have a higher total lesion score, particularly around the periventricular areas. This reached statistical significance in.the areas around the temporal horn. In all cases, neurological symptoms preceded the onset of psychosis. The psychotic group also had a later age of onset of psychosis than psychotic patients without brain disease. These results point to an aetiological association between the pathological process of MS and psychosis.
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收藏
页码:680 / 685
页数:6
相关论文
共 35 条
[1]   SCHIZOPHRENIA AND MULTIPLE-SCLEROSIS [J].
AWAD, AG .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 1983, 171 (05) :323-324
[2]  
CARPENTER WT, 1973, ARCH GEN PSYCHIAT, V28, P847
[3]  
CROW TJ, 1989, ARCH GEN PSYCHIAT, V46, P1145
[4]  
Davison K, 1969, CURRENT PROBLEMS NEU, P113
[5]   ACUTE PARANOID PSYCHOSIS IN MULTIPLE-SCLEROSIS [J].
DRAKE, ME .
PSYCHOSOMATICS, 1984, 25 (01) :60-&
[6]  
Du Boulay G, 1972, Acta Radiol Diagn (Stockh), V13, P496
[7]   PSYCHOSIS ASSOCIATED WITH DEMONSTRABLE BRAIN DISEASE [J].
FEINSTEIN, A ;
RON, MA .
PSYCHOLOGICAL MEDICINE, 1990, 20 (04) :793-803
[8]  
HARVEY I, 1992, IN PRESS REDUCTION C
[9]   TEMPORAL-LOBE INVOLVEMENT IN MULTIPLE-SCLEROSIS PATIENTS WITH PSYCHIATRIC-DISORDERS [J].
HONER, WG ;
HURWITZ, T ;
LI, DKB ;
PALMER, M ;
PATY, DW .
ARCHIVES OF NEUROLOGY, 1987, 44 (02) :187-190
[10]   MOOD DISORDER AND MULTIPLE-SCLEROSIS [J].
JOFFE, RT ;
LIPPERT, GP ;
GRAY, TA ;
SAWA, G ;
HORVATH, Z .
ARCHIVES OF NEUROLOGY, 1987, 44 (04) :376-378