THE HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY OF SULFATED TETRASACCHARIDES IS SENSITIVE TO STRUCTURAL VARIATION

被引：11

作者：

WESSEL, HP

VIEIRA, E

TRUMTEL, M

TSCHOPP, TB

IBERG, N

机构：

[1] Pharma Division, Preclinical Research F.HOFFMANN-LA ROCHE LTD

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00051-T

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The sulfated tetrasaccharide beta-maltosyl-(1-->4)-alpha,alpha-trehalose 2 with high antiproliferative activity on smooth muscle cells was modified in the maltosyl moiety by linking eight different disaccharides equatorially to trehalose; the biological activity varied strongly between different structures.

引用

收藏

页码：437 / 442

页数：6

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