TANDEMLY REPEATED PENTANUCLEOTIDES IN DNA-SEQUENCES OF EUKARYOTES

被引:12
作者
BORSTNIK, B [1 ]
PUMPERNIK, D [1 ]
LUKMAN, D [1 ]
UGARKOVIC, D [1 ]
PLOHL, M [1 ]
机构
[1] RUDJER BOSKOVIC INST,DEPT MOLEC GENET,ZAGREB 41000,CROATIA
关键词
D O I
10.1093/nar/22.16.3412
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genetic sequence data banks were scanned in order to retrieve tandemly repeated pentanucleotides (pnts). It was found that among 102 (=(1024 - 4)/2/5) possible distinct pnts roughly each fourth is involved in tandem repeats. It is shown that tandemly repeated pnts are composed of frequently occuring di- and trinucleotides and that those pnts which occur frequently in the form of mono- or di-pnts form also tandem repeats either in the form of satellites or in the form of shorter tandem repeats. Human satellite III is taken as a specific example. It is shown that the first guanine within GG-AAT pnt exhibits the highest mutability. Sequential distribution of base changes gives evidence that the mutations do not occur at random positions but in a correlated fashion so that long stretches of original pnts remain intact. It is found that pnts related to the satellite III are present in introns and flanking regions of some structural genes, but are not preserved between orthologous genes of related species. The results corroborate the most plausible mechanism of their evolution - rapid amplification followed by successive divergence of repeat units by various mutational processes.
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页码:3412 / 3417
页数:6
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共 39 条
  • [1] BASIC LOCAL ALIGNMENT SEARCH TOOL
    ALTSCHUL, SF
    GISH, W
    MILLER, W
    MYERS, EW
    LIPMAN, DJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
  • [2] GENBANK
    BENSON, D
    LIPMAN, DJ
    OSTELL, J
    [J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (13) : 2963 - 2965
  • [3] THE MOSAIC GENOME OF WARM-BLOODED VERTEBRATES
    BERNARDI, G
    OLOFSSON, B
    FILIPSKI, J
    ZERIAL, M
    SALINAS, J
    CUNY, G
    MEUNIERROTIVAL, M
    RODIER, F
    [J]. SCIENCE, 1985, 228 (4702) : 953 - 958
  • [4] THE ISOCHORE ORGANIZATION OF THE HUMAN GENOME
    BERNARDI, G
    [J]. ANNUAL REVIEW OF GENETICS, 1989, 23 : 637 - 661
  • [5] DNA METHYLATION AND THE FREQUENCY OF CPG IN ANIMAL DNA
    BIRD, AP
    [J]. NUCLEIC ACIDS RESEARCH, 1980, 8 (07) : 1499 - 1504
  • [6] ANALYSIS OF APPARENT 1/F-ALPHA SPECTRUM IN DNA-SEQUENCES
    BORSTNIK, B
    PUMPERNIK, D
    LUKMAN, D
    [J]. EUROPHYSICS LETTERS, 1993, 23 (06): : 389 - 394
  • [7] BORSTNIK B, 1994, INT J QUANT CHEM, V50
  • [8] CHOO KHA, 1992, AM J HUM GENET, V50, P706
  • [9] PURIFICATION OF CPG ISLANDS USING A METHYLATED DNA-BINDING COLUMN
    CROSS, SH
    CHARLTON, JA
    NAN, XS
    BIRD, AP
    [J]. NATURE GENETICS, 1994, 6 (03) : 236 - 244
  • [10] Dawkins R., 1976, SELFISH GENE