COMPETITION FOR FOLLICULAR NICHES EXCLUDES SELF-REACTIVE CELLS FROM THE RECIRCULATING B-CELL REPERTOIRE

被引：469

作者：

CYSTER, JG ^{[1
]}

HARTLEY, SB ^{[1
]}

GOODNOW, CC ^{[1
]}

机构：

[1] STANFORD UNIV, BECKMAN CTR, SCH MED, HOWARD HUGHES MED INST, STANFORD, CA 94305 USA

来源：

NATURE | 1994年 / 371卷 / 6496期

关键词：

D O I：

10.1038/371389a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective exclusion of self-antigen-binding B cells from the normal migration route into lymphoid follicles, resulting in their premature death. This is a striking example of homeostasis by cellular competition for limiting niches and may explain the paradoxical association between immunodeficiency and autoimmunity.

引用

页码：389 / 395

页数：7

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