Hydration of the DNA bases is local

被引：207

作者：

Schneider, B

Berman, HM

机构：

[1] ACAD SCI CZECH REPUBL,J HEYROVSKY INST PHYS CHEM,CR-18223 PRAGUE,CZECH REPUBLIC

[2] RUTGERS STATE UNIV,DEPT CHEM,NEW BRUNSWICK,NJ 08903

来源：

BIOPHYSICAL JOURNAL | 1995年 / 69卷 / 06期

关键词：

D O I：

10.1016/S0006-3495(95)80136-0

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ordered hydration sites were determined for the nucleotide bases in B-type conformations using the crystal structure data on 14 B-DNA decamer structures, A method of density representation was extended so that positions, occupancies, and distributions of the hydration sites were predicted around a B-DNA double helix by a method analogous to crystallographic refinement. The predicted hydration sites correctly reproduce the main features of hydration around the B-DNA dodecamer. In contrast to the previous observations, the newly available crystal data show the same extent of hydration of guanine and adenine, and of cytosine and thymine.

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页码：2661 / 2669

页数：9

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