PHOSPHONAMIDATES AND PHOSPHONAMIDATE ESTERS AS HIV-1 PROTEASE INHIBITORS

被引：79

作者：

MCLEOD, DA

BRINKWORTH, RI

ASHLEY, JA

JANDA, KD

WIRSCHING, P

机构：

[1] The Scripps Research Institute, Department of Molecular Biology and Chemistry, La Jolla, CA 92033

[2] The Centre for Drug Design and Development, The University of Queensland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)81171-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Simple dipeptides incorporating phosphonamidate and phosphonamidate ester isosteres for the scissile peptide bond are modest inhibitors of the HIV-1 protease. Their synthesis and inhibition studies are described.

引用

页码：653 / +

共 31 条

[1] PHOSPHINIC ACID DIPEPTIDE ANALOGS - POTENT, SLOW-BINDING INHIBITORS OF ASPARTIC PEPTIDASES
BARTLETT, PA
KEZER, WB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (15) : 4282 - 4283
[2] EVALUATION OF INTRINSIC BINDING-ENERGY FROM A HYDROGEN-BONDING GROUP IN AN ENZYME-INHIBITOR
BARTLETT, PA
MARLOWE, CK
[J]. SCIENCE, 1987, 235 (4788) : 569 - 571
[3] PHOSPHONAMIDATES AS TRANSITION-STATE ANALOG INHIBITORS OF THERMOLYSIN
BARTLETT, PA
MARLOWE, CK
[J]. BIOCHEMISTRY, 1983, 22 (20) : 4618 - 4624
[4] POTENT INHIBITION OF PEPSIN AND PENICILLOPEPSIN BY PHOSPHORUS-CONTAINING PEPTIDE ANALOGS
BARTLETT, PA
HANSON, JE
GIANNOUSIS, PP
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (26) : 6268 - 6274
[5] PHOSPHORUS-CONTAINING PEPTIDE ANALOGS AS PEPTIDASE INHIBITORS
BARTLETT, PA
MARLOWE, CK
GIANNOUSIS, PP
HANSON, JE
[J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1987, 52 : 83 - 90
[6] BILLICH S, 1988, J BIOL CHEM, V263, P17905
[7] BLUNDELL TL, 1990, TIBS, P15
[8] NOVEL RENIN INHIBITORS CONTAINING THE AMINO-ACID STATINE
BOGER, J
LOHR, NS
ULM, EH
POE, M
BLAINE, EH
FANELLI, GM
LIN, TY
PAYNE, LS
SCHORN, TW
LAMONT, BI
VASSIL, TC
STABILITO, II
VEBER, DF
RICH, DH
BOPARI, AS
[J]. NATURE, 1983, 303 (5912) : 81 - 84
[9] INHIBITION OF HIV-1 PROTEINASE BY NONPEPTIDE CARBOXYLATES
BRINKWORTH, RI
WOON, TC
FAIRLIE, DP
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (01) : 241 - 246
[10] COMPARISON OF CARBOXYPEPTIDASE-A AND THERMOLYSIN - INHIBITION BY PHOSPHONAMIDATES
CHRISTIANSON, DW
LIPSCOMB, WN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (16) : 5560 - 5565

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