GLUCOCORTICOID REGULATION OF HIPPOCAMPAL OXYTOCIN RECEPTOR-BINDING

被引：29

作者：

LIBERZON, I ^{[1
]}

CHALMERS, DT ^{[1
]}

MANSOUR, A ^{[1
]}

LOPEZ, JF ^{[1
]}

WATSON, SJ ^{[1
]}

YOUNG, EA ^{[1
]}

机构：

[1] VET ADM MED CTR, PSYCHIAT SERV, ANN ARBOR, MI 48105 USA

来源：

BRAIN RESEARCH | 1994年 / 650卷 / 02期

关键词：

SUBICULUM; IN VITRO AUTORADIOGRAPHY; ADRENALECTOMY; I-125] OVTA;

D O I：

10.1016/0006-8993(94)91798-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [I-125]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.

引用

页码：317 / 322

页数：6

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