THE METABOLISM OF ALICYCLIC AMINES TO REACTIVE IMINIUM ION INTERMEDIATES

被引：50

作者：

GORROD, JW

AISLAITNER, G

机构：

[1] Chelsea Department of Pharmacy, King's College London, London, SW3 6LX, Manresa Road

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1994年 / 19卷 / 03期

关键词：

ALICYCLIC AMINES; IMINIUM IONS; ALPHA-CARBONYL COMPOUNDS; COVALENT BINDING;

D O I：

10.1007/BF03188923

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The evidence implicating the formation of iminiumions as reactive intermediates in the metabolism of alicyclic amines has been reviewed. The mechanism of formation of iminium ions and their conversion to alpha-carbonyl compoounds or demethylated amines is discussed. The use of a simple cyanide trapping technique for iminium ions has been demonstrated to monitor a large number of alicyclic drugs for iminium ion formation. The possible role of iminium ions in the pharmacology and toxicology of alicyclic amines is considered.

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收藏

页码：209 / 217

页数：9

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