EVALUATION OF ASTEMIZOLE PURITY BY HPLC

被引：11

作者：

SURYANARAYANA, MV

VENKATARAMAN, S

REDDY, MS

REDDY, BP

SASTRY, CSP

KRUPADANAM, GLD

机构：

[1] ANDHRA UNIV,SCH CHEM,WALTAIR 530003,ANDHRA PRADESH,INDIA

[2] OSMANIA UNIV,DEPT CHEM,HYDERABAD 500007,ANDHRA PRADESH,INDIA

来源：

TALANTA | 1993年 / 40卷 / 09期

关键词：

D O I：

10.1016/0039-9140(93)80210-I

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A liquid chromatographic method is described for the evaluation of Astemizole purity. The method is also applicable for the analysis of pharmaceutical dosage forms of Astemizole using indole as internal standard. Separation was achieved with a mu bondapak C18 column and phosphate buffer (pH 6.0):acetonitrile (50:50 v/v) as eluent, at a flow rate of 1.5 ml/min with UV detection at 280 nm. The method is suitable for estimating the possible impurities if any present in Astemizole up to 0.05% for 1a and 0.25% for 1b. The method is simple, rapid and accurate for the analysis of Astemizole.

引用

页码：1357 / 1360

页数：4