ANTIBODY-DIRECTED TARGETING OF THE VASCULATURE OF SOLID TUMORS

被引:120
作者
THORPE, PE
BURROWS, FJ
机构
[1] Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, 75235-8593, Texas
关键词
ENDOTHELIAL CELLS; MONOCLONAL ANTIBODIES; SOLID TUMORS; TEC-11; ANTIBODY; THERAPY; VASCULAR TARGETING;
D O I
10.1007/BF00666044
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
An attractive strategy for the therapy of carcinomas and other solid tumors would be to target cytotoxic agents or host immune effecters to the endothelial cells of the tumor vasculature rather than to the tumor cells themselves. The key advantage of this approach is that the endothelial cells are freely accessible through the blood whereas the tumor cells are, for the most part, inaccessible. Also, endothelial cells are similar in different tumors, making it feasible to develop a single reagent for treating numerous types of cancer. In this chapter, we review progress in this ''vascular targeting'' approach, from the validation of the concept in a mouse model to the characterization of the TEC-11 antibody against endoglin, an endothelial cell proliferation marker that is upregulated on endothelial cells in miscellaneous human solid tumors. In addition, we review other tumor endothelial cell markers that are candidates for vascular targeting in man.
引用
收藏
页码:237 / 251
页数:15
相关论文
共 54 条
[1]   TRANSPORT OF FLUID AND MACROMOLECULES IN TUMORS .3. ROLE OF BINDING AND METABOLISM [J].
BAXTER, LT ;
JAIN, RK .
MICROVASCULAR RESEARCH, 1991, 41 (01) :5-23
[2]  
BRULAND OS, 1988, CANCER RES, V48, P5302
[3]  
BUHRING HJ, 1991, LEUKEMIA, V5, P841
[4]   ERADICATION OF LARGE SOLID TUMORS IN MICE WITH AN IMMUNOTOXIN DIRECTED AGAINST TUMOR VASCULATURE [J].
BURROWS, FJ ;
THORPE, PE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :8996-9000
[5]  
BURROWS FJ, 1992, CANCER RES, V52, P5954
[6]   TARGETING THE VASCULATURE OF SOLID TUMORS [J].
BURROWS, FJ ;
THORPE, PE .
JOURNAL OF CONTROLLED RELEASE, 1994, 28 (1-3) :195-202
[7]  
BURROWS FJ, UNPUB CLIN CANCER RE
[8]  
BYERS VS, 1988, IMMUNOLOGY, V65, P329
[9]   A TUMOR-ASSOCIATED FIBRONECTIN ISOFORM GENERATED BY ALTERNATIVE SPLICING OF MESSENGER-RNA PRECURSORS [J].
CARNEMOLLA, B ;
BALZA, E ;
SIRI, A ;
ZARDI, L ;
NICOTRA, MR ;
BIGOTTI, A ;
NATALI, PG .
JOURNAL OF CELL BIOLOGY, 1989, 108 (03) :1139-1148
[10]  
CHEIFETZ S, 1992, J BIOL CHEM, V267, P19027