COLON CANCER AND DIETARY FIBER - CELLULOSE INHIBITS THE DNA-DAMAGING ABILITY OF BILE-ACIDS

被引：16

作者：

CHEAH, PY

BERNSTEIN, H

机构：

[1] Department of Microbiology and Immunology and Committee on Genetics, College of Medicine, University of Arizona, Health Sciences Center, Tucson

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1990年 / 13卷 / 1-2期

关键词：

D O I：

10.1080/01635589009514044

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colon cancer is the second most common type of cancer in the United States. Bile acids have been implicated in the etiology of this disease. In a previous study, we showed that bile acids can damage DNA in vitro. In this study, we report that this damage is largely prevented when the bile acids are pretreated with cellulose fiber. Preliminary data show that cellulose may act as a catalyst to promote polyesterification of bile acid to a biologically inactive form. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：51 / 57

页数：7

共 20 条

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