LIGHT AND ELECTRON-MICROSCOPIC EXAMINATION OF AMYLOID-RICH PRIMITIVE PLAQUES - COMPARISON WITH DIFFUSE PLAQUES

被引：11

作者：

IKEDA, K ^{[1
]}

HAGA, C ^{[1
]}

KOSAKA, K ^{[1
]}

机构：

[1] PSYCHIAT RES INST TOKYO,DEPT NEUROPATHOL,SETAGAYA KU,TOKYO 156,JAPAN

来源：

JOURNAL OF NEUROLOGY | 1990年 / 237卷 / 02期

关键词：

Amyloid; Amyloid-rich primitive plaque; Diffuse plaque; Electron microscopy; Periodic-acid methenamine silver method;

D O I：

10.1007/BF00314668

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Alzheimer-type dementia brains, numerous "amyloid-rich primitive plaques (PPs)" were observed with β-protein immunostaining and periodicacid methenamine (PAM) staining. These amyloid-rich primitive plaques were accompanied by various degrees of small argyrophilic rod-like, granular or filamentous structures. Routine and modified-PAM electron microscopy revealed many bundles and flecks consisting of amyloid fibrils scattered widely throughout the plaques. Degenerate neurites, astrocytic processes and bundles of glial fibres also participated in the formation of the plaques. The similarities and differences between these amyloid-rich primitive plaques and diffuse plaques are described. © 1990 Springer-Verlag.

引用

页码：88 / 93

页数：6

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