SYNERAZOL, A NEW ANTIFUNGAL ANTIBIOTIC

被引：66

作者：

ANDO, O

SATAKE, H

NAKAJIMA, M

SATO, A

NAKAMURA, T

KINOSHITA, T

FURUYA, K

HANEISHI, T

机构：

[1] SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 305,JAPAN

[3] SANKYO CO LTD,DEPT INT DRUG DEV,CHUO KU,TOKYO 104,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 04期

关键词：

D O I：

10.7164/antibiotics.44.382

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.

引用

页码：382 / 389

页数：8

共 15 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].