SURVIVAL OF SCRAPIE VIRUS AFTER 3 YEARS INTERNMENT

被引：188

作者：

BROWN, P

GAJDUSEK, DC

机构：

[1] Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda

来源：

LANCET | 1991年 / 337卷 / 8736期

关键词：

D O I：

10.1016/0140-6736(91)90873-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Supernatant fluid from a scrapie-infected hamster brain homogenate was mixed with soil, packed into perforated petri dishes that were then embedded within soil-containing pots, and buried in a garden for 3 years. Between 2 and 3 log units of the input infectivity of nearly 5 log units survived this exposure, with little leaching of virus into deeper soil layers. These results have implications for environmental contamination by scrapie and by similar agents, including those of bovine spongiform encephalopathy and Creutzfeldt-Jakob disease.

引用

页码：269 / 270

页数：2