H-1-NMR AS AN ANALYTICAL TOOL FOR THE INVESTIGATION OF HYDROLYSIS RATES - A METHOD FOR THE RAPID EVALUATION OF THE SHELF-LIFE OF AQUEOUS-SOLUTIONS OF DRUGS WITH ESTER GROUPS

被引：6

作者：

FERDOUS, AJ ^{[1
]}

DICKINSON, NA ^{[1
]}

WAIGH, RD ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 12期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03195.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The rate of hydrolysis of esters of primary and secondary alcohols can be determined quickly and easily by H-1 NMR in aqueous solution, provided that the water signal is suppressed by the WATR (Water Attenuation by T2 Relaxation) method. To evaluate this approach. Arrhenius plots have been constructed for hydrolysis of acetylcholine, carbachol and atropine, and the effect of pH on the hydrolysis of procaine has been determined over a limited range. The results agree well with literature values for rate constants.

引用

页码：860 / 862

页数：3

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