REVERSED-PHASE LIQUID-CHROMATOGRAPHY USING MONOALKYLAMMONIUM COMPOUNDS IN THE MOBILE PHASE - EFFECTS OF MONOALKYLAMMONIUM CHAIN-LENGTH ON THE EFFICIENCY, SELECTIVITY AND SEPARATION OF XANTHINE AND URIC-ACID DERIVATIVES

被引：9

作者：

NALINE, E

PALETTEPAYS, C

MOREAU, J

ADVENIER, C

PAYS, M

机构：

[1] Département de Biochimie et de Pharmacologie, Hôpital André Mignot, F-78157 Le Chesnay

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 604卷 / 02期

关键词：

D O I：

10.1016/0021-9673(92)85129-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A systematic analysis of the influence of several chromatographic parameters on the adsorption of monoalkylammonium modifiers on a chemically bonded phase in reversed-phase high performance liquid chromatography is presented. The most important variables are the alkyl chain length, the concentration of the monoalkylammonium modifiers and the acetonitrile content in the mobile phase. The results can be applied to the separation and structure determination of xanthine and uric acid derivatives and to the study of retention mechanisms.

引用

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页码：203 / 211

页数：9

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