ISOLATION OF AN ISOMER OF FK-506 FROM FERMENTATION OF STREPTOMYCES-TSUKUBAENSIS AND ITS CHEMICAL SYNTHESIS FROM FK-506

被引：13

作者：

GRASSBERGER, MA

FEHR, T

HORVATH, A

SCHULZ, G

机构：

[1] Department of Dermatology, A-1235 Wien

来源：

TETRAHEDRON | 1992年 / 48卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(01)89004-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From the fermentation broth of Streptomyces tsukubaensis 9993 an isomer 2a of the immunosuppressant FK-506 1a was isolated as a minor metabolite. From NMR- and FAB-MS data follows that in 2a the size of the macrocycle is reduced by two carbon atoms due to a shift of the lactone-acyl from 0-26 to 0-24. The compound was synthesized from FK-506 and proved to be identical with the natural product 2a.

引用

页码：413 / 430

页数：18

共 19 条

[1] CHEMISTRY OF FK-506 - BENZILIC ACID REARRANGEMENT OF THE TRICARBONYL SYSTEM [J].