THE IMMUNOLOGY OF PRIMARY HIV-INFECTION - WHICH IMMUNE-RESPONSES CONTROL HIV REPLICATION

被引:45
作者
SAFRIT, JT [1 ]
KOUP, RA [1 ]
机构
[1] NYU, SCH MED, NEW YORK, NY 10016 USA
关键词
D O I
10.1016/0952-7915(95)80088-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the majority of patients, HIV-1 replication is quickly and efficiently controlled after the initial burst of viremia. Recent studies have begun to elucidate the underlying immune responses that may be responsible for this dramatic reduction in viral load. These responses include those of HIV-specific CD8(+) cytotoxic T lymphocytes and antibodies capable of binding the virus.
引用
收藏
页码:456 / 461
页数:6
相关论文
共 36 条
[1]   RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].
ALBERT, J ;
ABRAHAMSSON, B ;
NAGY, K ;
AURELIUS, E ;
GAINES, H ;
NYSTROM, G ;
FENYO, EM .
AIDS, 1990, 4 (02) :107-112
[2]   IS CLEARANCE OF HIV-1 VIREMIA AT SEROCONVERSION MEDIATED BY NEUTRALIZING ANTIBODIES [J].
ARIYOSHI, K ;
HARWOOD, E ;
CHIENGSONGPOPOV, R ;
WEBER, J .
LANCET, 1992, 340 (8830) :1257-1258
[3]   SEVERE HERPESVIRUS INFECTIONS IN AN ADOLESCENT WITHOUT NATURAL-KILLER CELLS [J].
BIRON, CA ;
BYRON, KS ;
SULLIVAN, JL .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (26) :1731-1735
[4]   VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].
BORROW, P ;
LEWICKI, H ;
HAHN, BH ;
SHAW, GM ;
OLDSTONE, MBA .
JOURNAL OF VIROLOGY, 1994, 68 (09) :6103-6110
[5]   ADOPTIVE TRANSFER STUDIES DEMONSTRATING THE ANTIVIRAL EFFECT OF NATURAL-KILLER CELLS INVIVO [J].
BUKOWSKI, JF ;
WARNER, JF ;
DENNERT, G ;
WELSH, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 161 (01) :40-52
[6]   BIOLOGY OF CLONED CYTO-TOXIC LYMPHOCYTES-T SPECIFIC FOR LYMPHOCYTIC CHORIOMENINGITIS VIRUS - CLEARANCE OF VIRUS INVIVO [J].
BYRNE, JA ;
OLDSTONE, MBA .
JOURNAL OF VIROLOGY, 1984, 51 (03) :682-686
[7]   HIGH TITERS OF CYTOPATHIC VIRUS IN PLASMA OF PATIENTS WITH SYMPTOMATIC PRIMARY HIV-1 INFECTION [J].
CLARK, SJ ;
SAAG, MS ;
DECKER, WD ;
CAMPBELLHILL, S ;
ROBERSON, JL ;
VELDKAMP, PJ ;
KAPPES, JC ;
HAHN, BH ;
SHAW, GM .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (14) :954-960
[8]   CLEARANCE OF HIV-1 VIREMIA AFTER SEROCONVERSION [J].
CLEMENTI, M ;
BAGNARELLI, P ;
MENZO, S ;
VALENZA, A ;
MANZIN, A ;
VARALDO, PE .
LANCET, 1993, 341 (8840) :315-316
[9]   IMPAIRED CYTOTOXIC T-LYMPHOCYTE RECOGNITION DUE TO GENETIC VARIATIONS IN THE MAIN IMMUNOGENIC REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS-1 NEF PROTEIN [J].
COUILLIN, I ;
CULMANNPENCIOLELLI, B ;
GOMARD, E ;
CHOPPIN, J ;
LEVY, JP ;
GUILLET, JG ;
SARAGOSTI, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) :1129-1134
[10]   TRANSIENT HIGH-LEVELS OF VIREMIA IN PATIENTS WITH PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].
DAAR, ES ;
MOUDGIL, T ;
MEYER, RD ;
HO, DD .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (14) :961-964