GENOMIC STRUCTURE OF AN ATTENUATED QUASI-SPECIES OF HIV-1 FROM A BLOOD-TRANSFUSION DONOR AND RECIPIENTS

被引：1014

作者：

DEACON, NJ

TSYKIN, A

SOLOMON, A

SMITH, K

LUDFORDMENTING, M

HOOKER, DJ

MCPHEE, DA

GREENWAY, AL

ELLETT, A

CHATFIELD, C

LAWSON, VA

CROWE, S

MAERZ, A

SONZA, S

LEARMONT, J

SULLIVAN, JS

CUNNINGHAM, A

DWYER, D

DOWTON, D

MILLS, J

机构：

[1] MACFARLANE BURNET CTR MED RES, NATL CTR HIV VIROL RES, AIDS MOLEC BIOL UNIT, YARRA BEND RD, FAIRFIELD, VIC 3078, AUSTRALIA

[2] MACFARLANE BURNET CTR MED RES, NATL CTR HIV VIROL RES, AIDS CELLULAR BIOL UNIT, FAIRFIELD, VIC 3078, AUSTRALIA

[3] MACFARLANE BURNET CTR MED RES, NATL CTR HIV VIROL RES, AIDS PATHOGENESIS UNIT, FAIRFIELD, VIC 3078, AUSTRALIA

[4] NEW S WALES RED CROSS, BLOOD TRANSFUS SERV, SYDNEY 2000, NSW, AUSTRALIA

[5] WESTMEAD HOSP, DEPT VIROL, WESTMEAD, NSW 2145, AUSTRALIA

[6] WESTMEAD HOSP, NATL CTR HIV VIROL RES, INST CLIN PATHOL & MED RES, WESTMEAD, NSW 2145, AUSTRALIA

来源：

SCIENCE | 1995年 / 270卷 / 5238期

关键词：

D O I：

10.1126/science.270.5238.988

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of six blood or blood product recipients infected from this donor remain free of HIV-1-related disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1 sequences from either virus isolates or patient peripheral blood mononuclear cells had similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification of selected HIV-1 genome regions from other cohort members revealed no other abnormalities of obvious functional significance. These data show that survival after HIV infection can be determined by the HIV genome and support the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1.

引用

页码：988 / 991

页数：4

共 40 条

[1] PRODUCTION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED RETROVIRUS IN HUMAN AND NONHUMAN CELLS TRANSFECTED WITH AN INFECTIOUS MOLECULAR CLONE [J].

ADACHI, A ;

GENDELMAN, HE ;

KOENIG, S ;

FOLKS, T ;

WILLEY, R ;

RABSON, A ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1986, 59 (02) :284-291

[2]

ARCHER G, 1988, 4TH INT C AIDS STOCK

[3] INCUBATION PERIODS FOR PEDIATRIC AIDS PATIENTS [J].

AUGER, I ;

THOMAS, P ;

DEGRUTTOLA, V ;

MORSE, D ;

MOORE, D ;

WILLIAMS, R ;

TRUMAN, B ;

LAWRENCE, CE .

NATURE, 1988, 336 (6199) :575-577

[4] VIROLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION OF LONG-TERM SURVIVORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

CAO, YZ ;

QIN, LM ;

ZHANG, LQ ;

SAFRIT, J ;

HO, DD .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (04) :201-208

[5]

Centers for Disease Control and Prevention, 1992, MMWR-MORBID MORTAL W, V41, P961

[6] PROTECTIVE EFFECTS OF A LIVE ATTENUATED SIV VACCINE WITH A DELETION IN THE NEF GENE [J].

DANIEL, MD ;

KIRCHHOFF, F ;

CZAJAK, SC ;

SEHGAL, PK ;

DESROSIERS, RC .

SCIENCE, 1992, 258 (5090) :1938-1941

[7] DEVELOPMENT AND VALIDATION OF A POLYMERASE CHAIN-REACTION METHOD FOR THE PRECISE QUANTITATION OF HIV-1 DNA IN BLOOD-CELLS FROM SUBJECTS UNDERGOING A 1-YEAR IMMUNOTHERAPEUTIC TREATMENT [J].

FERRE, F ;

MARCHESE, AL ;

GRIFFIN, SL ;

DAIGLE, AE ;

RICHIERI, SP ;

JENSEN, FC ;

CARLO, DJ .

AIDS, 1993, 7 :S21-S27

[8] PHENOTYPE-ASSOCIATED SEQUENCE VARIATION IN THE 3RD VARIABLE DOMAIN OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 MOLECULE [J].

FOUCHIER, RAM ;

GROENINK, M ;

KOOTSTRA, NA ;

TERSMETTE, M ;

HUISMAN, HG ;

MIEDEMA, F ;

SCHUITEMAKER, H .

JOURNAL OF VIROLOGY, 1992, 66 (05) :3183-3187

[9]

GOODALL J, 1994, THESIS U MELBOURNE

[10]

GOU LH, 1982, NUCLEIC ACIDS RES, V10, P2065

← 1 2 3 4 →