A CASE OF NEURAL CELL-ADHESION MOLECULE-POSITIVE PERIPHERAL T-CELL LYMPHOMA ASSOCIATED WITH HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE-1 SHOWING AN UNUSUAL INVOLVEMENT OF THE GASTROINTESTINAL-TRACT DURING THE COURSE OF THE DISEASE

被引：11

作者：

HAYASHI, K

NAKAMURA, S

KOSHIKAWA, T

KITOH, K

KOIKE, K

KOMATSU, H

KASAHARA, M

UEDA, R

SUCHI, T

KURODA, M

机构：

[1] AICHI CANC CTR HOSP,DEPT PATHOL & CLIN LABS,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[2] AICHI CANC CTR HOSP,DEPT INTERNAL MED,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[3] AICHI CANC CTR,RES INST,NAGOYA,AICHI 464,JAPAN

[4] FUJITA HLTH UNIV,SCH MED,DEPT PATHOL,TOYOAKE,AICHI,JAPAN

来源：

HUMAN PATHOLOGY | 1994年 / 25卷 / 11期

关键词：

PERIPHERAL T-CELL LYMPHOMA; NEURAL CELL ADHESION MOLECULE; CD56; HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE 1; ADULT T-CELL LEUKEMIA/LYMPHOMA;

D O I：

10.1016/0046-8177(94)90045-0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report a case of neural cell adhesion molecule (NCAM)-positive peripheral T-cell lymphoma (PTCL), pleomorphic, medium and large cell type according to the updated Kiel classification, which was associated with human T-cell lymphotrophic virus type 1 (HTLV-1). The patient showed an unusual involvement of the gastrointestinal tract forming a bulky mass during the course of his disease, and a relatively indolent clinical course for 53 months until death. Phenotypic analysis showed CD2+, CD3-, CD4+, CD5+, CD7+, CD8-, CD16-, CD56+, and CD57- phenotype. Human T-cell lymphotrophic virus type 1 antibody was detected by the enzyme-linked immunosorbent assay. The proviral integration of HTLV-1 and the monoclonal rearrangement of T-cell receptor beta and gamma genes also were confirmed in DNA extract from fresh material. This fact calls attention to NCAM as one of the potatial factors playing a role an the localization and behavior of lymphomas even within the category of PTCL associated with HTLV-1, ie, adult T-cell leukemia/lymphoma (ATLL). (C) 1994 by W.B. Saunders Company

引用

页码：1251 / 1253

页数：3

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