NONDISJUNCTION IN HUMAN SPERM - EVIDENCE FOR AN EFFECT OF INCREASING PATERNAL AGE

被引：163

作者：

GRIFFIN, DK

ABRUZZO, MA

MILLIE, EA

SHEEAN, LA

FEINGOLD, E

SHERMAN, SL

HASSOLD, TJ

机构：

[1] CASE WESTERN RESERVE UNIV, DEPT GENET, CLEVELAND, OH 44106 USA

[2] CASE WESTERN RESERVE UNIV, CTR HUMAN GENET, CLEVELAND, OH 44106 USA

[3] UNIV HOSP CLEVELAND, CLEVELAND, OH 44106 USA

[4] CASE WESTERN RESERVE UNIV, DEPT REPROD BIOL, CLEVELAND, OH 44106 USA

[5] EMORY UNIV, SCH PUBL HLTH, DIV BIOSTAT, ATLANTA, GA 30322 USA

[6] EMORY UNIV, SCH MED, DEPT MOLEC & MED GENET, ATLANTA, GA 30322 USA

来源：

HUMAN MOLECULAR GENETICS | 1995年 / 4卷 / 12期

关键词：

D O I：

10.1093/hmg/4.12.2227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In humans, the relationship between advancing maternal age and the incidence of trisomy has been long established, but the possible effect of increasing age of the father remains controversial. Using a fluorescence in situ hybridization (FISH) approach to directly examine individual sperm for aneuploidy of the sex chromosomes and chromosome 18, we have analyzed similar to 400 000 sperm from 24 men aged 18-60 years. There was no obvious relationship between increasing age and disomy 18, but the incidence of XY, YY and XX disomy all were significantly elevated among older men. This suggests that older men, like older women, have an increased likelihood of producing aneuploid offspring by comparison with their younger counterparts.

引用

页码：2227 / 2232

页数：6

共 44 条

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