RECOMBINANT DERIVATIVES OF PASTEURELLA-MULTOCIDA TOXIN - CANDIDATES FOR A VACCINE AGAINST PROGRESSIVE ATROPHIC RHINITIS

被引：38

作者：

PETERSEN, SK

FOGED, NT

BORDING, A

NIELSEN, JP

RIEMANN, HK

FRANDSEN, PL

机构：

[1] NATL VET LAB,ANIM BIOTECHNOL RES CTR,DK-1503 COPENHAGEN V,DENMARK

[2] NO DRUGS & CHEM LTD,DK-2100 COPENHAGEN 0,DENMARK

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 04期

关键词：

D O I：

10.1128/IAI.59.4.1387-1393.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Potential vaccine components for protection against atrophic thinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a lack of toxic activity. One such component was shown to induce efficient protection of vaccinated female mice and their offspring against challenge with purified P. multocida toxin.

引用

页码：1387 / 1393

页数：7

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