THEONEZOLIDE-A - A NOVEL POLYKETIDE NATURAL PRODUCT FROM THE OKINAWAN MARINE SPONGE THEONELLA SP

被引：42

作者：

KOBAYASHI, J

KONDO, K

ISHIBASHI, M

WALCHLI, MR

NAKAMURA, T

机构：

[1] BRUKER JAPAN CO,NINOMIYA,TSUKUBA 305,JAPAN

[2] SANKYO CO LTD,ANALYT & METAB RES LAB,TOKYO 140,JAPAN

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 15期

关键词：

D O I：

10.1021/ja00068a024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Theonezolide A (1), a novel macrolide, has been isolated from the Okinawan marine sponge Theonella sp. and the planar structure elucidated on the basis of extensive spectroscopic analyses of 1 and its four ozonolysis products. Recent 2D NMR techniques of gradient-enhanced HMBC and HSQC-HOHAHA along with the FABMS/MS experiment were applied and proved to be quite efficient for structural study of this long aliphatic molecule. Theonezolide A (1), C79H140N4O22S2, is the first member of a new class of polyketide natural products consisting of two principal fatty acid chains with various functionalities such as a sulfate ester, an oxazole, and a thiazole group, constituting a 37-membered macrocyclic lactone ring bearing a long side chain attached through an amide linkage.

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页码：6661 / 6665

页数：5

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