THE PUNAGLANDINS - 10-CHLOROPROSTANOIDS FROM THE OCTOCORAL TELESTO-RIISEI

被引：44

作者：

BAKER, BJ ^{[1
]}

SCHEUER, PJ ^{[1
]}

机构：

[1] UNIV HAWAII MANOA, DEPT CHEM, HONOLULU, HI 96822 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 10期

关键词：

D O I：

10.1021/np50112a003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Telesto riisei, an octocoral from Hawaii, produces nineteen highly functionalized prostanoids, the punaglandins, which are characterized by various oxygenation at C-5, -6, -7, and -12, and a 10-chloro-3-cyclopencenone moiety. The absolute stereochemistry of the 10-chloroprostanoids is epimeric to that of the Pacific marine prosranoids without halogen. The punaglandins have shown anti-inflammatory and antitumor activity. A synthetic 10-thiomethyl derivative enhances in vivo mineralization in human osceoblasts.

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页码：1346 / 1353

页数：8

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