THE EXON-INTRON STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE MOUSE MACROPHAGE MANNOSE RECEPTOR GENE MRCL - IDENTIFICATION OF A RICIN-LIKE DOMAIN AT THE N-TERMINUS OF THE RECEPTOR

The macrophage mannose receptor is a transmembrane protein that is expressed on the surface of mature macrophages. The ectodomain of the receptor contains multiple domains, eight of which belong to the calcium-dependent C-type lectin family. The mannose receptor binds to carbohydrate polymers that have a high content of mannose. This property allows this protein to function as a phagocytic receptor that participates in first-line host defense against invading microorganisms. In this paper we describe the intron-exon structure of the mouse macrophage mannose receptor gene which was found to span at least 70 kilobases. We also report the localization of this gene, termed MrcI, to mouse Chromosome 2. Like its human counterpart, Mrcl contains 30 exons and 29 introns. A protein module that resembles a subdomain of the B chain of the plant lectin Ricin has been found within the N-terminal cysteine-rich domain of the mannose receptor. © 1994 Academic Press, Inc.