AN ATTEMPT TO ATTENUATE EXPERIMENTAL PAIN IN HUMANS BY DEXTROMETHORPHAN, AN NMDA RECEPTOR ANTAGONIST

被引：44

作者：

KAUPPILA, T

GRONROOS, M

PERTOVAARA, A

机构：

[1] HELSINKI UNIV,DEPT PHYSIOL,SF-00014 HELSINKI,FINLAND

[2] UNIV TURKU,DEPT PHYSIOL,TURKU,FINLAND

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 52卷 / 03期

关键词：

ANALGESIA; CAPSAICIN; DEXTROMETHORPHAN; N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST; PAIN MODULATION;

D O I：

10.1016/0091-3057(95)00106-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Dextromethorphan (100 mg, orally), an NMDA receptor antagonist, did not significantly attenuate pain intensity or unpleasantness induced by experimental ischemia or by topical capsaicin in healthy human subjects, nor did it increase the threshold for heat pain or mechanical pain. A dose of 200 mg produced marked side effects. Thus, systemically administered dextromethorphan does not attenuate pain at clinically applicable doses in humans.

引用

页码：641 / 644

页数：4

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