CYTOKINES SUPPRESS THE SHEAR STRESS-STIMULATED RELEASE OF VASOACTIVE PEPTIDES FROM HUMAN ENDOTHELIAL-CELLS

被引：6

作者：

BODIN, P ^{[1
]}

MILNER, P ^{[1
]}

MARSHALL, J ^{[1
]}

BURNSTOCK, G ^{[1
]}

机构：

[1] UCL, DEPT ANAT & DEV BIOL, LONDON WC1E 6BT, ENGLAND

来源：

PEPTIDES | 1995年 / 16卷 / 08期

关键词：

SHEAR STRESS; ENDOTHELIAL CELLS; CYTOKINES; VASOACTIVE PEPTIDES; RELEASE;

D O I：

10.1016/0196-9781(95)02040-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial cells from human umbilical vein perfused at 0.5 ml/min released vasopressin, endothelin, and substance P. Upon perfusion of the cells at 3.0 ml/min, the release of endothelin and vasopressin was significantly increased whereas the release of substance P was significantly decreased. Endothelial cells precultured for 24 h with interleukin-1 (IL-1) and interferon-gamma (IFN-gamma) released more endothelin and less substance P at low Bow and there was no further increase in release at high flow rate. These results suggest that cytokines suppress the normal responses of endothelial cells to increased fluid shear stress.

引用

收藏

页码：1433 / 1438

页数：6

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