SUBSTRATE SPECIFICITIES OF MITOCHONDRIAL THYMIDINE KINASE AND CYTOSOLIC DEOXYCYTIDINE KINASE AGAINST 5-ARYL SUBSTITUTED PYRIMIDINE-2'-DEOXYRIBOSE ANALOGS

被引：12

作者：

ERIKSSON, S

WANG, JH

机构：

[1] LUND UNIV,CTR CHEM,S-22100 LUND,SWEDEN

[2] MED AB,S-14144 HUDDINGE,SWEDEN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012414

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some 5-aryl-2'-deoxyuridine and -deoxycytidine analogues, many with known antiviral activity, were evaluated as substrates for pure deoxycytidine kinase (dCK) and pure mitochondrial thymidine kinase (TK2). Some of the deoxyuridine compounds were also tested with pure cytosolic thymidine kinase (TK1). TK2 showed the highest activity with this type of analogues.

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页码：507 / 510

页数：4

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