REPETITIVE SEQUENCE ELEMENTS IN AN INITIATION LOCUS OF THE AMPLIFIED DIHYDROFOLATE-REDUCTASE DOMAIN IN CHO CELLS

被引：17

作者：

LEU, TH

ANACHKOVA, B

HAMLIN, JL

机构：

[1] UNIV VIRGINIA, SCH MED, DEPT BIOCHEM, CHARLOTTESVILLE, VA 22908 USA

[2] UNIV VIRGINIA, SCH MED, CELL & MOLEC BIOL PROGRAM, CHARLOTTESVILLE, VA 22908 USA

来源：

GENOMICS | 1990年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0888-7543(90)90178-W

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have previously demonstrated that one of the replication initiation loci in the dihydrofolate reductase (DHFR) domain of Chinese hamster cells contains a repeated sequence that is enriched in the early-replicating fraction of the Chinese hamster genome. Here we present the sequence of the initiation locus, identify the relevant repeated element, and show that, while this element is enriched in early-replicating DNA, its synthesis is not confined to early S. © 1990.

引用

收藏

页码：428 / 433

页数：6

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