CARDIOVASCULAR EFFECTS OF SMOKING

被引：26

作者：

MANCIA, G ^{[1
]}

GROPPELLI, A ^{[1
]}

CASADEI, R ^{[1
]}

OMBONI, S ^{[1
]}

MUTTI, E ^{[1
]}

PARATI, G ^{[1
]}

机构：

[1] CTR AUXOL ITALIANO PIANCAVALLO,MILAN,ITALY

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1990年 / 12卷 / 05期

关键词：

Blood pressure; Cardioprotection; Coronary circulation; Coronary heart disease; Smoking; Sympathetic nervous system;

D O I：

10.3109/10641969009073509

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary heart disease (CHD) increases with smoking and this factor interacts with hypercholesterolemia and hypertension in raising the incidence of this condition in a greater than linear fashion. This can be explained by the adverse effect of smoking on plasma fibrogen, platelet turnover and lipid profile. It may also be accounted for, however, by the acute bradycardia, increase in blood pressure and generalized vasoconstriction accompanying smoking, due to a nicotine-dependent activation of the sympathetic nervous system. These effects (which in heavy smokers can raise blood pressure permanently) are only partly offset by beta-blockers and can only be abolished by opposing the cardiac and vascular sympathetic influences by alpha and beta-blockade combined. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：917 / 929

页数：13

共 22 条

[1] THE PROSPECTIVE CARDIOVASCULAR MUNSTER STUDY - PREVALENCE AND PROGNOSTIC-SIGNIFICANCE OF HYPERLIPIDEMIA IN MEN WITH SYSTEMIC HYPERTENSION [J].