HEPATITIS-E VIRUS GENOME - MOLECULAR-FEATURES, EXPRESSION OF IMMUNOREACTIVE PROTEINS AND SEQUENCE DIVERGENCE

被引：15

作者：

BRADLEY, DW ^{[1
]}

PURDY, MA ^{[1
]}

REYES, GR ^{[1
]}

机构：

[1] GENELABS INC,REDWOOD CITY,CA

来源：

JOURNAL OF HEPATOLOGY | 1991年 / 13卷

关键词：

D O I：

10.1016/0168-8278(91)90049-H

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The strategy for molecular cloning of hepatitis E virus (HEV), the major etiologic agent of enterically-transmitted non-A, non-B hepatitis, is briefly described. The organization of the HEV genome is discussed and compared to those of two other vertebrate viruses that contain single-stranded, positive-sense, polyadenylated RNA genomes with three overlapping ORFs. Serologic cross-reactivity of expressed proteins and genetic divergence of HEV isolates are also described within the context of sequence variation, type-common epitopes, and type-specific epitopes.

引用

页码：S152 / S154

页数：3

共 9 条

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