EFFECT OF ANTICONVULSANT FELBAMATE ON GABA-A RECEPTOR SYSTEM

被引：49

作者：

TICKU, MK ^{[1
]}

KAMATCHI, GL ^{[1
]}

SOFIA, RD ^{[1
]}

机构：

[1] WALLACE LABS,CRANBURY,NJ 08512

来源：

EPILEPSIA | 1991年 / 32卷 / 03期

关键词：

ANTIEPILEPTIC DRUGS; FELBAMATE; GABA-A RECEPTOR COMPLEX; RADIOLIGAND BINDING; CL-36-INFLUX; CULTURED SPINAL CORD NEURONS;

D O I：

10.1111/j.1528-1157.1991.tb04667.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Felbamate (FBM, 2-phenyl-1,3-propanediol dicarbamate), a potential antiepileptic drug (AED), has an unknown mechanism of action. We examined possible interaction of FBM with GABA(A)ergic transmission. FBM did not alter specific binding of ligands to GABA, benzodiazepine, and picrotoxin sites of the oligomeric GABA(A) receptor complex to rat brain membranes, nor did it enhance the effect of GABA on Cl-36-influx in well-characterized cultured spinal cord neurons. These results suggest that the anticonvulsant effect of FBM does not involve GABA(A)ergic transmission.

引用

页码：389 / 391

页数：3

共 17 条

[1]

HAEFELY W, 1977, INT J NEUROL, V12, P53

[2] THE PHARMACOLOGICAL PROPERTIES OF GABA RECEPTOR-COUPLED CHLORIDE CHANNELS USING CL-36-INFLUX IN CULTURED SPINAL-CORD NEURONS [J].