NEONATAL THROMBOSIS WITH ANTICARDIOLIPIN ANTIBODY IN BABY AND MOTHER

被引:29
作者
CONTRACTOR, S [1 ]
HIATT, M [1 ]
KOSMIN, M [1 ]
KIM, HC [1 ]
机构
[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT MED & PEDIAT,NEW BRUNSWICK,NJ 08903
关键词
D O I
10.1055/s-2007-999276
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The anticardiolipin antibody is associated with increased risk of thrombosis, which is manifested with various clinical presentations, including vascular thrombosis, recurrent fetal wastage, and neurologic defects. We report a case of neonatal thrombosis occurring in the renal vein and inferior vena cava associated with moderate positive anticardiolipin antibody titer in the baby while the maternal serum showed even stronger anticardiolipin antibody of immunoglobulin G class. Subsequent follow-up over the 4 months postpartum period showed a disappearance of the antibody in the baby, whereas the mother's antibody persisted. This case illustrates the fact that the maternal anticardiolipin antibody can be transferred to the fetus and may be a risk factor for thrombosis in the neonates. Anticardiolipin antibody syndrome should be considered in the differential diagnosis of neonatal thrombosis.
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页码:409 / 410
页数:2
相关论文
共 7 条
[1]  
Harris E.H., Annotation: And phospholipid antibodies, Br J Haematol, 74, pp. 1-9, (1990)
[2]  
Love P.E., Santoro S.A., Anti phospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders, Ann lutein Med, 112, pp. 682-698, (1990)
[3]  
Lockshin M.D., Qamar T., Druzin M.L., Goel S., Antibody to cardiolipin, lupus anticoagulant, and fetal death. J Rheumatol, 14, pp. 259-262, (1987)
[4]  
Andrew M., Schmidt B., The use of heparin in the newborn infant, Semin Thromb Hemost, 14, pp. 28-32, (1988)
[5]  
Corrigan J.J., Neonatal thrombosis and the thrombolytic system: pathophysiology and therapy, Am J Pediatr Hematol Oncol, 10, pp. 83-91, (1988)
[6]  
Gross K.R., Petty R.E., Lum V.L., Allen R.C., Maternal autoantibodies and letal disease, Clin Exp Rheumatol, 7, pp. 651-657, (1989)
[7]  
Watson R., Kang J.E., May M., Et al., Thrombocytopenia in the neonatal lupus syndrome, Arch Dermatol, 124, pp. 560-563, (1988)