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MIDKINE, A NOVEL NEUROTROPHIC FACTOR, PROMOTES SURVIVAL OF MESENCEPHALIC NEURONS IN CULTURE

被引：56
作者：
KIKUCHI, S
MURAMATSU, H
MURAMATSU, T
KIM, SU
机构：
[1] KAGOSHIMA UNIV,FAC MED,DEPT BIOCHEM,KAGOSHIMA 890,JAPAN
[2] UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL,VANCOUVER V6T 1W5,BC,CANADA
来源：
NEUROSCIENCE LETTERS | 1993年 / 160卷 / 01期
基金：
英国医学研究理事会;
关键词：
DOPAMINE UPTAKE; MESENCEPHALON; MIDKINE (MK); NEURONAL SURVIVAL; NEUROTROPHIC FACTOR; TYROSINE HYDROXYLASE;
D O I：
10.1016/0304-3940(93)90904-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Midkine (MK), a retinoic acid responsive gene product, is a novel neurotrophic factor with a molecular weight of 14,000. MK at the optimal concentration of 10 ng/ml promoted the survival of mouse mesencephalic neurons in culture as demonstrated by the increased number of microtubule-associated protein-2 (MAP2) immunostaining-positive and tyrosine hydroxylase immunostaining-positive neurons and an elevated uptake of radiolabeled dopamine, These results suggest that MK has ubiquitous neurotrophic activity towards mesencephalic neurons which contain a large number of dopaminergic neurons.
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页码：9 / 12
页数：4
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